By Rory A. Fisher

RGS Protein body structure and Pathophysiology describes the present, state of the art learn happening within the laboratories of leaders within the RGS protein box that make the most of genetic mouse versions to interrogate the functionality of RGS proteins in vivo.

Each bankruptcy describes the elucidated function of a particular RGS protein or kin of RGS proteins in common body structure and/or ailment with specific emphasis on how those discoveries tell healthcare and drug discovery.

The paintings is a well timed reference as medicines focusing on G protein coupled receptors characterize forty% of at present advertised therapeutics.

  • Brings jointly details at the present country of the RGS protein field
  • Contains accomplished descriptions of the recognized pathophysiological and physiological features of RGS proteins, the 1st such undertaking
  • Gives specific emphasis to the methods those discoveries tell healthcare and drug discovery

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Neubig 55. Hornquist CE, Lu X, Rogers-Fani PM, et al. G(alpha)i2-deficient mice with colitis exhibit a local increase in memory CD4 + T cells and proinflammatory Th1-type cytokines. J Immunol. 1997;158(3):1068–1077. 56. Luscher C, Jan LY, Stoffel M, Malenka RC, Nicoll RA. G protein-coupled inwardly rectifying K + channels (GIRKs) mediate postsynaptic but not presynaptic transmitter actions in hippocampal neurons. Neuron. 1997;19(3):687–695. 57. Raymond JR, Mukhin YV, Gelasco A, et al. Multiplicity of mechanisms of serotonin receptor signal transduction.

High expression levels in cones of RGS9, the predominant GTPase accelerating protein of rods. Proc Natl Acad Sci USA. 1998;95(9):5351–5356. 56. Zhang X, Wensel TG, Kraft TW. GTPase regulators and photoresponses in cones of the eastern chipmunk. J Neurosci. 2003;23(4):1287–1297. 57. Chen CK, Eversole-Cire P, Zhang H, et al. Instability of GGL domain-containing RGS proteins in mice lacking the G protein beta-subunit Gbeta5. Proc Natl Acad Sci USA. 2003;100(11):6604–6609. 58. Krispel CM, Chen D, Melling N, et al.

50. Watson AJ, Aragay AM, Slepak VZ, Simon MI. A novel form of the G protein beta subunit Gbeta5 is specifically expressed in the vertebrate retina. J Biol Chem. 1996;271(45):28154–28160. 51. Hu G, Wensel TG. R9AP, a membrane anchor for the photoreceptor GTPase accelerating protein, RGS9-1. Proc Natl Acad Sci USA. 2002;99(15):9755–9760. 52. Makino ER, Handy JW, Li T, Arshavsky VY. The GTPase activating factor for transducin in rod photoreceptors is the complex between RGS9 and type 5 G protein beta subunit.

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