By C. Schiepers (auth.), Christiaan Schiepers MD, PhD (eds.)

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1993; KIM et al. 1990; YOSHI et al. 1993; DIERCKX et al. 1994; RICCI et al. 1996). The discovery that 201Tl accumulates in neoplastic tissue was serendipitous because it was observed in patients undergoing myocardial perfusion studies who also had tumors. The uptake of 2Ü1TI in brain tumors is related to blood flow, BBB integrity and malignant cell density, and is due to its similarities with potassium and thus on the Na+,K+,ATP-ase activity. 2Ü1Tl uptake is also related to tumor type: as the rate of uptake differs, 2ü1Tl cannot be used as a partial substitute for histologie characterization and grading.

Nonfunctioning pituitary adenomas, as weIl as meningiomas and craniopharyngiomas, do not cause any specific endocrine syndrome; thus, their presence is usually suggested by the evidence of compression of the parasellar nervous structures. Radiologie differential diagnosis may occasionaIly be difficult in primary paraseHar lesions with presentation in the parasellar region. Diagnostic uncertainty after MRI investigation occurs in up to 10% of patients with hormonally inactive tumors of the sellar region.

J Nucl Med 31:1007-1014 Benson DF, Kuhl DE, Hawkins RA, Phelps ME, Cummings JL, Tsai SY (1983) The fluorodeoxyglucoseßF scan in Neurochemieal Imaging with Emission Tomography: Clinical Applications Alzheimer's disease and multi-infarct dementia. Arch Neuro140:711-714 Bergstrom M, Muhr C, Lundberg PO, Berstrom K, Lundqvist H, Antoni G, Fasth K-G, Langstrom B (1987) In vivo study of amino acid distribution and metabolism in pituitary adenomas using positron emission tomography with llC_D_ methionine and llC-L-methionine.

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