By Claudio Hetz

During this ebook, scientists pioneering the sector have compiled a chain of concentrated chapters to spotlight the relevance of the BCL‑2 kin of proteins in apoptosis, body structure and sickness. a massive concentration of this quantity is thinking about the aptitude TH period PEUT IC merits of focusing on apoptosis pathways within the context of human affliction. Readers attracted to figuring out how a phone handles pressure and the results of dysregulation of this strategy for human sickness will locate this booklet very helpful. It makes an attempt to explain a desirable sector of analysis the place body structure and biomedicine converge at diverse degrees, revealing a visit from the molecular legislation of apoptosis to the effect of this technique to the body structure of a complete organism.

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Am J Physiol Cell Physiol 2000; 278(2):C423-435. 76. Jouaville LS, Pinton P, Bastianutto C et al. Regulation of mitochondrial ATP synthesis by calcium: evidence for a long-term metabolic priming. Proc Natl Acad Sci USA 1999; 96(24):13807-13812. 77. Szalai G, Krishnamurthy R, Hajnoczky G. Apoptosis driven by IP(3)-linked mitochondrial calcium signals. EMBO J 1999; 18(22):6349-6361. 78. Pacher P, Hajnoczky G. Propagation of the apoptotic signal by mitochondrial waves. EMBO J 2001; 20(15):4107-4121.

Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol 2003; 4(7):517-529. 40. Orrenius S, Zhivotovsky B, Nicotera P. Regulation of cell death: the calcium-apoptosis link. Nat Rev Mol Cell Biol 2003; 4(7):552-565. Homeostatic Functions of BCL-2 Proteins beyond Apoptosis 25 41. Rong Y, Distelhorst CW. BCL-2 protein family members: versatile regulators of calcium signaling in cell survival and apoptosis. Annu Rev Physiol 2008; 70:73-91. 42. Germain M, Mathai JP, McBride HM et al.

J Cell Biol 2004; 166(2):193-203. 59. Oakes SA, Scorrano L, Opferman JT et al. Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum. Proc Natl Acad Sci USA 2005; 102(1):105-110. 60. Dremina ES, Sharov VS, Kumar K et al. Anti-apoptotic protein BCL-2 interacts with and destabilizes the sarcoplasmic/endoplasmic reticulum Ca2 -ATPase (SERCA). Biochem J 2004; 383(Pt 2):361-370. 61. Dremina ES, Sharov VS, Schoneich C. Displacement of SERCA from SR lipid caveolae-related domains by BCL-2: a possible mechanism for SERCA inactivation.

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