By Denis Dochain

Giving an summary of the demanding situations within the keep an eye on of bioprocesses, this entire publication offers key ends up in numerous fields, together with: dynamic modeling; dynamic houses of bioprocess types; software program sensors designed for the online estimation of parameters and nation variables; regulate and supervision of bioprocesses.

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Extra resources for Automatic Control of Bioprocesses (Control Systems, Robotics and Manufacturing)

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N. A. A RISTIDOU and J. N IELSEN, Metabolic Engineering. Principles and Methodologies, Academic Press, San Diego, 1998. [WAL 97] E. WALTER and L. P RONZATO, Identification of Parametric Models from Experimental Data, Springer-Verlag, Heidelberg, 1997. W. C. A. L EWANDOWSKI, “Kinetics of phenol biodegradation in the presence of glucose”, Biotechnol. , vol. 51, pp. 87–94, 1996. 1. Introduction The complexity of dynamic bioprocess models, which are usually employed, is actually a reflection of the complexity of the processes themselves as well as of the detailed knowledge about them acquired over the course of the past decades.

Lastly, we should not neglect the final modeling stage: validation of the model. During this phase, quality of the model must be tested in the most objective way possible, and the operating domains for which it reaches its limits must be identified. In this chapter, we were interested only in the models for processes assumed to be infinitely mixed, and only these spatially homogenous systems will be considered in this book. Dynamic Models of Biochemical Processes: Properties of Models 43 Finally, let us note that here we restricted ourselves to the knowledge models, resulting from physical considerations.

It is necessary to have an expression relating reaction rates to some variables of the system. However, it should be remembered that they are generally approximate relationships based on empirical considerations, and that we thus move away from the physical modeling established in the preceding section. In this chapter, we will see how to treat assumptions made on the kinetics level on a hierarchical basis and thus arrive at a description based on two reliability levels of the kinetics. 2. 1.

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