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Additional resources for ASME Bio Process Equipment (BPE) 2005

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F) Steam service valves shall be capable of being regularly maintained, either in- or out-of-line. ASME BPE-2005 BIOPROCESSING EQUIPMENT Compendial water distribution loop Compendial water distribution loop Sample point Process equipment connection Clean gas or clean steam Min. Min. Min. --``````,,`,`,,`,,,`,,,,,,`,,,-`-`,,`,,`,`,,`--- Min. Process equipment Min. (b) Direct Connect to Equpiment Drain/steam trap/ sample point Process equipment Compendial water distribution loop (a) Hard Piped to Equpiment Point-of-use/ sample valve Physical break Compendial water distribution loop Sink Drain (d) Sink Min.

D) The gap between the steady bearing and shaft shall be sufficiently large to allow free access of cleaning fluids. (e) Mechanical seal glands on agitators shall be designed to accept a thermocouple temperature sensor, to verify the sterility of the gland area. in. mm in. 1 (g) Welded shell and tube heat exchangers shall be of a double tubesheet design to prevent product contamination in the case of a tube joint failure (see Fig. SD-20). (1) During fabrication, when the tubes are to be expanded into the inner and outer tubesheets, the product contact surface must not be scored.

1 ⁄8 in. 5%) (c) Skidded Runs. /ft (21 mm/m or approximately 2%) (d) Transfer Panels. 1⁄4 in. 5%). 16 The system shall be designed to eliminate air pockets, and prevent or minimize air entrainment. 5 times the nominal tube diameter to prevent the deterioration of interior surfaces, (wrinkling, striations, and potential cracking). ) are used. 18 Ball valves are not recommended in fluid hygienic piping systems. 2(b) for further comments. 19 Plate and frame type heat exchangers should be used only by agreement between owner and designer due to the difficulty of CIP and SIP.

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